Enantioselectivity of Pentedrone and Methylone on Metabolic Profiling in 2D and 3D Human Hepatocyte-like Cells

Pentedrone and methylone can express stereoselectivity in toxicokinetic and toxicodynamic processes. Similarly, their chiral discrimination in metabolism, which was not yet evaluated, can result in different metabolic profiles and subsequent hepatotoxic effects. Therefore, the aim of this work was t...

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Detalles Bibliográficos
Autores principales: Silva, Bárbara, Rodrigues, Joana Saraiva, Almeida, Ana Sofia, Lima, Ana Rita, Fernandes, Carla, Guedes de Pinho, Paula, Miranda, Joana Paiva, Remião, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953427/
https://www.ncbi.nlm.nih.gov/pubmed/35337165
http://dx.doi.org/10.3390/ph15030368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953427/
https://www.ncbi.nlm.nih.gov/pubmed/35337165
http://dx.doi.org/10.3390/ph15030368

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