Cargando…

Development and Performance Verification of the PBPK Model for Antazoline and Its Metabolite and Its Utilization for Pharmacological Hypotheses Formulating

Antazoline is an antihistaminic drug that is effective in the termination of paroxysmal atrial fibrillation. Despite its long presence in the market, antazoline’s ADME parameters and pharmacokinetic effects in humans are poorly characterized. The objective of this study was to fill this gap by gener...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wiśniowska, Barbara, Giebułtowicz, Joanna, Piotrowski, Roman, Kułakowski, Piotr, Polak, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953460/ https://www.ncbi.nlm.nih.gov/pubmed/35337175 http://dx.doi.org/10.3390/ph15030379

Ejemplares similares

Characterization of In Vitro and In Vivo Metabolism of Antazoline Using Liquid Chromatography-Tandem Mass Spectrometry
por: Giebułtowicz, Joanna, et al.
Publicado: (2020)

Magnetic Core–Shell Molecularly Imprinted Nano-Conjugates for Extraction of Antazoline and Hydroxyantazoline from Human Plasma—Material Characterization, Theoretical Analysis and Pharmacokinetics
por: Giebułtowicz, Joanna, et al.
Publicado: (2021)

Pharmacological Cardioversion With Antazoline in Atrial Fibrillation: The Results of the CANT Study
por: Wybraniec, Maciej T., et al.
Publicado: (2018)

PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human
por: Campbell, Jerry L., et al.
Publicado: (2016)

Effect of Antazoline on Electrophysiological Properties of Atrial Muscle and Conduction System of the Heart
por: Bińkowski, Bartłomiej Jacek, et al.
Publicado: (2018)

Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?
por: Esh, Christopher J., et al.
Publicado: (2021)

Quality Control Dissolution Data Is Biopredictive for a Modified Release Ropinirole Formulation: Virtual Experiment with the Use of Re-Developed and Verified PBPK Model
por: Shuklinova, Olha, et al.
Publicado: (2022)

Where Do PBPK Models Stand in Pharmacometrics and Systems Pharmacology?
por: Jamei, Masoud
Publicado: (2020)

Formulating Hypotheses for Different Study Designs
por: Misra, Durga Prasanna, et al.
Publicado: (2021)

Editorial: Exploring Maternal-Fetal Pharmacology Through PBPK Modeling Approaches
por: Dallmann, André, et al.
Publicado: (2022)

Curcumin and its nano-formulations: Defining triple-negative breast cancer targets through network pharmacology, molecular docking, and experimental verification
por: Deng, Zhicheng, et al.
Publicado: (2022)

Daily ECG transmission versus serial 6-day Holter ECG for the assessment of efficacy of ablation for atrial fibrillation — the AGNES-ECG study
por: Sikorska, Agnieszka, et al.
Publicado: (2022)

Performance Evaluation of Montelukast Pediatric Formulations: Part II — a PBPK Modelling Approach
por: Guimarães, Mariana, et al.
Publicado: (2022)

Ablation for paroxysmal atrial fibrillation—real-life results from a middle-volume electrophysiology laboratory
por: Kulakowski, Piotr, et al.
Publicado: (2021)

Development, Verification, and Prediction of Osimertinib Drug–Drug Interactions Using PBPK Modeling Approach to Inform Drug Label
por: Pilla Reddy, Venkatesh, et al.
Publicado: (2018)

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
por: Kuepfer, L, et al.
Publicado: (2016)

A four-compartment PBPK heart model accounting for cardiac metabolism - model development and application
por: Tylutki, Zofia, et al.
Publicado: (2017)

Selective Binding of Cyclodextrins with Leflunomide and Its Pharmacologically Active Metabolite Teriflunomide
por: Terekhova, Irina, et al.
Publicado: (2020)

Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates
por: Polak, Sebastian, et al.
Publicado: (2015)

Comprehensive Parent–Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies
por: Kovar, Lukas, et al.
Publicado: (2020)

Formulation of metoclopramide HCl gastroretentive film and in vitro- in silico prediction using Gastroplus® PBPK software
por: Safaa Hamdi, Dalia, et al.
Publicado: (2022)

Developing a Formulation Strategy Coupled with PBPK Modeling and Simulation for the Weakly Basic Drug Albendazole
por: Shah, Harsh, et al.
Publicado: (2023)

Model reduction in mathematical pharmacology: Integration, reduction and linking of PBPK and systems biology models
por: Snowden, Thomas J., et al.
Publicado: (2018)

Erratum: Development, Verification, and Prediction of Osimertinib Drug–Drug Interactions Using PBPK Modeling Approach to Inform Drug Label
Publicado: (2019)

Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene
por: Campbell, J. L., et al.
Publicado: (2023)

Piperine and Its Metabolite’s Pharmacology in Neurodegenerative and Neurological Diseases
por: Azam, Shofiul, et al.
Publicado: (2022)

PBPK modeling of ivermectin—Considerations for the purpose of developing alternative routes to optimize its safety profile
por: Rowland Yeo, Karen, et al.
Publicado: (2023)

Formulation development, in vivo bioequivalence and pediatric PBPK modeling studies of taste-masked ciprofloxacin chewable tablets
por: Usmani, Muhammad Talha, et al.
Publicado: (2023)

Is catheter-tissue contact force value important for ablation of ventricular arrhythmias originating from the left ventricular papillary muscles?
por: Baran, Jakub, et al.
Publicado: (2023)

Development of Novel Herbal Compound Formulations Targeting Neuroinflammation: Network Pharmacology, Molecular Docking, and Experimental Verification
por: Liu, Yang, et al.
Publicado: (2023)

Effects of 1α,25-Dihydroxyvitamin D(3) on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach
por: Balla, Anusha, et al.
Publicado: (2021)

Meticulous parade on naringin respecting its pharmacological activities and novel formulations
por: Alam, Mahboob, et al.
Publicado: (2022)

RIVAroxaban TWICE daily for lysis of thrombus in the left atrial appendage in patients with non-valvular atrial fibrillation: the RIVA-TWICE study
por: Piotrowski, Roman, et al.
Publicado: (2019)

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK
por: Wagner, C, et al.
Publicado: (2015)

Analysis of biomarker utility using a PBPK/PD model for carbaryl
por: Phillips, Martin B., et al.
Publicado: (2014)

Applied Concepts in PBPK Modeling: How to Extend an Open Systems Pharmacology Model to the Special Population of Pregnant Women
por: Dallmann, André, et al.
Publicado: (2018)

Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation
por: Bagdas, Deniz, et al.
Publicado: (2020)

Cotinine: Pharmacologically Active Metabolite of Nicotine and Neural Mechanisms for Its Actions
por: Tan, Xiaoying, et al.
Publicado: (2021)

Workshop: Toward Unification and its Verification
por: Kazama, Y, et al.
Publicado: (1985)

In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part III
por: Witkowski, Jakub, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_l5ei020aiav3c0r1qd1h8pla97