Cargando…

Development of the Validated Stability-Indicating Method for the Determination of Vortioxetine in Bulk and Pharmaceutical Formulation by HPLC-DAD, Stress Degradation Kinetics Studies and Detection of Degradation Products by LC-ESI-QTOF-MS

Vortioxetine (VOR) is a new antidepressant drug used to treat major depressive disorder. In this work, a novel, simple, rapid, accurate, precise, selective, stability-indicating, and fully validated high-performance liquid chromatography method with diode array detection (HPLC-DAD) was developed to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wróblewski, Karol, Szultka-Młyńska, Małgorzata, Janiszewska, Daria, Petruczynik, Anna, Buszewski, Bogusław
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953571/ https://www.ncbi.nlm.nih.gov/pubmed/35335245 http://dx.doi.org/10.3390/molecules27061883

Ejemplares similares

Comparison of Various Chromatographic Systems for Identification of Vortioxetine in Bulk Drug Substance, Human Serum, Saliva, and Urine Samples by HPLC-DAD and LC-QTOF-MS
por: Petruczynik, Anna, et al.
Publicado: (2020)

Development and Validation of LC-MS/MS Method for Determination of Cytisine in Human Serum and Saliva
por: Wróblewski, Karol, et al.
Publicado: (2023)

Determination of Selected Isoquinoline Alkaloids from Mahonia aquifolia; Meconopsis cambrica; Corydalis lutea; Dicentra spectabilis; Fumaria officinalis; Macleaya cordata Extracts by HPLC-DAD and Comparison of Their Cytotoxic Activity
por: Petruczynik, Anna, et al.
Publicado: (2019)

Molecularly Imprinted Polymers as Solid-Phase Microextraction Fibers for the Isolation of Selected Antibiotics from Human Plasma
por: Szultka-Młyńska, Małgorzata, et al.
Publicado: (2021)

Identification of In Vitro Metabolites of Amoxicillin in Human Liver Microsomes by LC–ESI/MS
por: Szultka, Malgorzata, et al.
Publicado: (2014)

Isoquinoline Alkaloid Contents in Macleaya cordata Extracts and Their Acetylcholinesterase and Butyrylcholinesterase Inhibition
por: Tuzimski, Tomasz, et al.
Publicado: (2022)

“Omic” Approaches to Bacteria and Antibiotic Resistance Identification
por: Janiszewska, Daria, et al.
Publicado: (2022)

HPLC-DAD-ESI-QTOF-MS/MS qualitative analysis data and HPLC-DAD quantification data of phenolic compounds of grains from five Australian sorghum genotypes
por: Xiong, Yun, et al.
Publicado: (2020)

Study of in-vitro metabolism of selected antibiotic drugs in human liver microsomes by liquid chromatography coupled with tandem mass spectrometry
por: Szultka-Mlynska, Malgorzata, et al.
Publicado: (2016)

Determination of Some Isoquinoline Alkaloids in Extracts Obtained from Selected Plants of the Ranunculaceae, Papaveraceae and Fumarioideae Families by Liquid Chromatography and In Vitro and In Vivo Investigations of Their Cytotoxic Activity
por: Misiurek, Justyna, et al.
Publicado: (2023)

Identification of Bacteria Associated with Post-Operative Wounds of Patients with the Use of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Approach
por: Szultka-Młyńska, Małgorzata, et al.
Publicado: (2021)

Chemical Profiling of an Antimigraine Herbal Preparation, Tianshu Capsule, Based on the Combination of HPLC, LC-DAD-MS(n), and LC-DAD-ESI-IT-TOF/MS Analyses
por: Liang, Juanjuan, et al.
Publicado: (2014)

Quantitative and Qualitative Analysis of Flavonoids and Phenolic Acids in Snow Chrysanthemum (Coreopsis tinctoria Nutt.) by HPLC-DAD and UPLC-ESI-QTOF-MS
por: Yang, Yinjun, et al.
Publicado: (2016)

Determination and Identification of Antibiotic Drugs and Bacterial Strains in Biological Samples
por: Pauter, Katarzyna, et al.
Publicado: (2020)

Kinetics and Characterization of Degradation Products of Dihydralazine and Hydrochlorothiazide in Binary Mixture by HPLC-UV, LC-DAD and LC–MS Methods
por: Gumieniczek, Anna, et al.
Publicado: (2018)

Glucosinolates and Isothiocyantes in Processed Rapeseed Determined by HPLC-DAD-qTOF
por: Miklavčič Višnjevec, Ana, et al.
Publicado: (2021)

Determination of Cytotoxic Activity of Sanguinaria canadensis Extracts against Human Melanoma Cells and Comparison of Their Cytotoxicity with Cytotoxicity of Some Anticancer Drugs
por: Tuzimski, Tomasz, et al.
Publicado: (2021)

Determination of Cytotoxic Activity of Selected Isoquinoline Alkaloids and Plant Extracts Obtained from Various Parts of Mahonia aquifolium Collected in Various Vegetation Seasons
por: Tuzimski, Tomasz, et al.
Publicado: (2021)

Rapid characterization of ginsenosides in the roots and rhizomes of Panax ginseng by UPLC-DAD-QTOF-MS/MS and simultaneous determination of 19 ginsenosides by HPLC-ESI-MS
por: Wang, Hong-Ping, et al.
Publicado: (2016)

HPLC-DAD-ESI-QTOF-MS Determination of Bioactive Compounds and Antioxidant Activity Comparison of the Hydroalcoholic and Water Extracts from Two Helichrysum italicum Species
por: Kramberger, Katja, et al.
Publicado: (2020)

Comprehensive Quality Assessment of Kaixin Powder by HPLC–DAD Quantification and HPLC–QTOF-MS/MS Confirmation
por: Wang, Binbin, et al.
Publicado: (2021)

Determination of Selected Isoquinoline Alkaloids from Chelidonium majus, Mahonia aquifolium and Sanguinaria canadensis Extracts by Liquid Chromatography and Their In Vitro and In Vivo Cytotoxic Activity against Human Cancer Cells
por: Tuzimski, Tomasz, et al.
Publicado: (2023)

An Integrated LC-ESI-MS(n) and High Resolution LC-ESI-QTOF Approach for the Identification of Phloroglucinols from Nepalese Hypericum japonicum
por: Peron, Gregorio, et al.
Publicado: (2020)

LC-ESI-QTOF-MS/MS Characterization of Seaweed Phenolics and Their Antioxidant Potential
por: Zhong, Biming, et al.
Publicado: (2020)

LC-ESI/QTOF-MS Profiling of Chicory and Lucerne Polyphenols and Their Antioxidant Activities
por: Iqbal, Yasir, et al.
Publicado: (2021)

Identification and Content of Astaxanthin and Its Esters from Microalgae Haematococcus pluvialis by HPLC-DAD and LC-QTOF-MS after Extraction with Various Solvents
por: Todorović, Biljana, et al.
Publicado: (2021)

A Different Perspective on the Characterization of a New Degradation Product of Flibanserin With HPLC–DAD–ESI-IT-TOF-MS(n) and Its Pharmaceutical Formulation Analysis With Inter-Laboratory Comparison
por: Geven, Aysun, et al.
Publicado: (2023)

Chromatographic fingerprints analysis and determination of seven components in Danmu preparations by HPLC–DAD/QTOF-MS
por: Li, Nanxin, et al.
Publicado: (2020)

Characterization of flavonoids in Millettia nitida var. hirsutissima by HPLC/DAD/ESI-MS(n)
por: Ye, Min, et al.
Publicado: (2012)

Diversity and Content of Carotenoids and Other Pigments in the Transition from the Green to the Red Stage of Haematococcus pluvialis Microalgae Identified by HPLC-DAD and LC-QTOF-MS
por: Grujić, Veno Jaša, et al.
Publicado: (2022)

The LC-QTOF-MS/MS analysis of acid degradation products of Rifaximin, an antibiotic
por: Yaseen, Saima Baig, et al.
Publicado: (2022)

New approaches for extraction and determination of betaine from Beta vulgaris samples by hydrophilic interaction liquid chromatography-tandem mass spectrometry
por: Rivoira, Luca, et al.
Publicado: (2017)

Characterization and Quantification of Nonanthocyanin Phenolic Compounds in White and Blue Bilberry (Vaccinium myrtillus) Juices and Wines Using UHPLC-DAD−ESI-QTOF-MS and UHPLC-DAD
por: Liu, Shuxun, et al.
Publicado: (2020)

Combining HPLC-DAD-QTOF-MS and HPLC-SPE-NMR to Monitor In Vitro Vitetrifolin D Phase I and II Metabolism
por: Sturm, Sonja, et al.
Publicado: (2021)

Characterization of forced degradation products of toloxatone by LC-ESI-MS/MS
por: Skibiński, Robert, et al.
Publicado: (2018)

Application of HPLC-DAD for In Vitro Investigation of Acetylcholinesterase Inhibition Activity of Selected Isoquinoline Alkaloids from Sanguinaria canadensis Extracts
por: Tuzimski, Tomasz, et al.
Publicado: (2021)

LC-DAD–ESI-MS/MS and NMR Analysis of Conifer Wood Specialized Metabolites
por: Patyra, Andrzej, et al.
Publicado: (2022)

Development of novel molecularly imprinted solid-phase microextraction fibers and their application for the determination of antibiotic drugs in biological samples by SPME-LC/MS(n)
por: Szultka, Malgorzata, et al.
Publicado: (2012)

Screening for cytotoxic chemical constituents from Justicia procumbens by HPLC–DAD–ESI–MS and NMR
por: Liu, Bo, et al.
Publicado: (2018)

HPLC-DAD-ESI-MS Analysis of Flavonoids from Leaves of Different Cultivars of Sweet Osmanthus
por: Wang, Yiguang, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_k84e28v5elhqmb0l4qpdtmrklb