Factors Influencing the Intracellular Concentrations of the Sofosbuvir Metabolite GS-331007 (in PBMCs) at 30 Days of Therapy

Sofosbuvir (SOF) is an HCV NS5B polymerase inhibitor, and GS-331007 is its major metabolite. The aim of this study was to investigate whether clinical and pharmacological factors could influence GS-331007 intracellular (IC) concentrations in peripheral blood mononuclear cells (PBMCs) associated with...

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Detalles Bibliográficos
Autores principales: Cusato, Jessica, Boglione, Lucio, De Nicolò, Amedeo, Caviglia, Gian Paolo, Mornese Pinna, Simone, Ciancio, Alessia, Troshina, Giulia, Smedile, Antonina, Antonucci, Miriam, Avataneo, Valeria, Palermiti, Alice, Mula, Jacopo, Manca, Alessandra, Cariti, Giuseppe, Cantù, Marco, Saracco, Giorgio Maria, Di Perri, Giovanni, D’Avolio, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953593/
https://www.ncbi.nlm.nih.gov/pubmed/35337152
http://dx.doi.org/10.3390/ph15030355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953593/
https://www.ncbi.nlm.nih.gov/pubmed/35337152
http://dx.doi.org/10.3390/ph15030355

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