Cargando…

Factors Influencing the Intracellular Concentrations of the Sofosbuvir Metabolite GS-331007 (in PBMCs) at 30 Days of Therapy

Sofosbuvir (SOF) is an HCV NS5B polymerase inhibitor, and GS-331007 is its major metabolite. The aim of this study was to investigate whether clinical and pharmacological factors could influence GS-331007 intracellular (IC) concentrations in peripheral blood mononuclear cells (PBMCs) associated with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cusato, Jessica, Boglione, Lucio, De Nicolò, Amedeo, Caviglia, Gian Paolo, Mornese Pinna, Simone, Ciancio, Alessia, Troshina, Giulia, Smedile, Antonina, Antonucci, Miriam, Avataneo, Valeria, Palermiti, Alice, Mula, Jacopo, Manca, Alessandra, Cariti, Giuseppe, Cantù, Marco, Saracco, Giorgio Maria, Di Perri, Giovanni, D’Avolio, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953593/ https://www.ncbi.nlm.nih.gov/pubmed/35337152 http://dx.doi.org/10.3390/ph15030355

Ejemplares similares

Antiretroviral Levels in the Cerebrospinal Fluid: The Effect of Inflammation and Genetic Variants
por: Cusato, Jessica, et al.
Publicado: (2023)

Seasonal Variation of Antiretroviral Drug Exposure during the Year: The Experience of 10 Years of Therapeutic Drug Monitoring
por: Cusato, Jessica, et al.
Publicado: (2021)

Analytical Validation and Clinical Application of Rapid Serological Tests for SARS-CoV-2 Suitable for Large-Scale Screening
por: De Nicolò, Amedeo, et al.
Publicado: (2021)

Long-Term Pharmacokinetics of Dalbavancin in ABSSSI and Osteoarticular Settings: A Real-Life Outpatient Context
por: De Nicolò, Amedeo, et al.
Publicado: (2021)

Vitamin D as Modulator of Drug Concentrations: A Study on Two Italian Cohorts of People Living with HIV Administered with Efavirenz
por: Cusato, Jessica, et al.
Publicado: (2021)

Monthly Increase in Vitamin D Levels upon Supplementation with 2000 IU/Day in Healthy Volunteers: Result from “Integriamoci”, a Pilot Pharmacokinetic Study
por: Avataneo, Valeria, et al.
Publicado: (2022)

Development and Validation of an Up-to-Date Highly Sensitive UHPLC-MS/MS Method for the Simultaneous Quantification of Current Anti-HIV Nucleoside Analogues in Human Plasma
por: De Nicolò, Amedeo, et al.
Publicado: (2021)

Antifungal Drug Plasma Exposures: A Possible Contribution of Vitamin D-Related Gene Variants
por: Cusato, Jessica, et al.
Publicado: (2022)

COVID-19: Focusing on the Link between Inflammation, Vitamin D, MAPK Pathway and Oxidative Stress Genetics
por: Cusato, Jessica, et al.
Publicado: (2023)

Stability Study of Fosfomycin in Elastomeric Pumps at 4 °C and 34 °C: Technical Bases for a Continuous Infusion Use for Outpatient Parenteral Antibiotic Therapy
por: Manca, Alessandra, et al.
Publicado: (2023)

A Non-Invasive Method for Detection of Antihypertensive Drugs in Biological Fluids: The Salivary Therapeutic Drug Monitoring
por: Avataneo, Valeria, et al.
Publicado: (2022)

25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2
por: D’Avolio, Antonio, et al.
Publicado: (2020)

COVID-19: A Possible Contribution of the MAPK Pathway
por: Cusato, Jessica, et al.
Publicado: (2023)

Clinical Effectiveness and Pharmacokinetics of Dalbavancin in Treatment-Experienced Patients with Skin, Osteoarticular, or Vascular Infections
por: Stroffolini, Giacomo, et al.
Publicado: (2022)

Validation of a UHPLC-MS/MS Method to Quantify Twelve Antiretroviral Drugs within Peripheral Blood Mononuclear Cells from People Living with HIV
por: De Nicolò, Amedeo, et al.
Publicado: (2020)

Long-Term Hepatocellular Carcinoma Development and Predictive Ability of Non-Invasive Scoring Systems in Patients with HCV-Related Cirrhosis Treated with Direct-Acting Antivirals
por: Caviglia, Gian Paolo, et al.
Publicado: (2022)

The hepatitis D virus in Italy. A vanishing infection, not yet a vanished disease
por: Caviglia, Gian Paolo, et al.
Publicado: (2021)

Usefulness of a Hepatitis B Surface Antigen-Based Model for the Prediction of Functional Cure in Patients with Chronic Hepatitis B Virus Infection Treated with Nucleos(t)ide Analogues: A Real-World Study
por: Caviglia, Gian Paolo, et al.
Publicado: (2021)

Vitamin D-Related Genetics as Predictive Biomarker of Clinical Remission in Adalimumab-Treated Patients Affected by Crohn’s Disease: A Pilot Study
por: Cusato, Jessica, et al.
Publicado: (2021)

Changes in Liver Stiffness and Markers of Liver Synthesis and Portal Hypertension following Hepatitis C Virus Eradication in Cirrhotic Individuals
por: Armandi, Angelo, et al.
Publicado: (2022)

A Novel UHPLC-MS/MS Method for the Quantification of Seven Opioids in Different Human Tissues
por: Manca, Alessandra, et al.
Publicado: (2023)

Etiology of chronic liver diseases in the Northwest of Italy, 1998 through 2014
por: Saracco, Giorgio Maria, et al.
Publicado: (2016)

Clinical Application of Droplet Digital PCR for Hepatitis Delta Virus Quantification
por: Olivero, Antonella, et al.
Publicado: (2022)

Pregnancy and COVID-19: The Possible Contribution of Vitamin D
por: Manca, Alessandra, et al.
Publicado: (2022)

Occult Hepatitis B Virus Infection in Patients With Chronic Hepatitis C Treated With Antiviral Therapy
por: Caviglia, Gian Paolo, et al.
Publicado: (2012)

Pharmacokinetic of Cefiderocol in Critically Ill Patients Receiving Renal Replacement Therapy: A Case Series
por: Mornese Pinna, Simone, et al.
Publicado: (2022)

Monitoring Tacrolimus Concentrations in Whole Blood and Peripheral Blood Mononuclear Cells: Inter- and Intra-Patient Variability in a Cohort of Pediatric Patients
por: De Nicolò, Amedeo, et al.
Publicado: (2021)

Sofosbuvir and daclatasvir
por: Hessel, Marleen H. M., et al.
Publicado: (2016)

Sofosbuvir‐based therapies in genotype 2 hepatitis C virus cirrhosis: A real‐life experience with focus on ribavirin dose
por: Smirne, Carlo, et al.
Publicado: (2021)

Alpha-Fetoprotein, Protein Induced by Vitamin K Absence or Antagonist II and Glypican-3 for the Detection and Prediction of Hepatocellular Carcinoma in Patients with Cirrhosis of Viral Etiology
por: Caviglia, Gian Paolo, et al.
Publicado: (2020)

Epidemiology, patient profile, and health care resource use for hepatitis C in Italy
por: Sangiorgi, Diego, et al.
Publicado: (2017)

Possible Impact of Vitamin D Status and Supplementation on SARS-CoV-2 Infection Risk and COVID-19 Symptoms in a Cohort of Patients with Inflammatory Bowel Disease
por: De Nicolò, Amedeo, et al.
Publicado: (2022)

Behind the scenes of GS: preventing and curing - the GS-SE group
por: CERN, GS-SE
Publicado: (2013)

Evaluation of Posaconazole Pharmacokinetics in Adult Patients with Invasive Fungal Infection
por: Allegra, Sarah, et al.
Publicado: (2017)

Identification of the Best Cut-Off Value of PIVKA-II for the Surveillance of Patients at Risk of Hepatocellular Carcinoma Development
por: Caviglia, Gian Paolo, et al.
Publicado: (2023)

High Efficacy and Safety of Flat-Dose Ribavirin Plus Sofosbuvir/Daclatasvir in Genotype 3 Cirrhotic Patients
por: Pellicelli, Adriano, et al.
Publicado: (2020)

Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease Patients
por: Ribaldone, Davide Giuseppe, et al.
Publicado: (2019)

Coronavirus disease 2019 and first-trimester spontaneous abortion: a case-control study of 225 pregnant patients
por: Cosma, Stefano, et al.
Publicado: (2021)

Analysis of Cannabinoids Concentration in Cannabis Oil Galenic Preparations: Harmonization between Three Laboratories in Northern Italy
por: Palermiti, Alice, et al.
Publicado: (2021)

GS BBQ 2015
por: Rueda, Laura
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_tn8b1vefc0qfe6vc61f30cib55