Conformational flexibility of apolipoprotein A-I amino- and carboxy-termini is necessary for lipid binding but not cholesterol efflux

Because of its critical role in HDL formation, significant efforts have been devoted to studying apolipoprotein A-I (APOA1) structural transitions in response to lipid binding. To assess the requirements for the conformational freedom of its termini during HDL particle formation, we generated three...

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Detalles Bibliográficos
Autores principales: Bedi, Shimpi, Morris, Jamie, Shah, Amy, Hart, Rachel C., Jerome, W. Gray, Aller, Stephen G., Tang, Chongren, Vaisar, Tomas, Bornfeldt, Karin E., Segrest, Jere P., Heinecke, Jay W., Davidson, W. Sean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953623/
https://www.ncbi.nlm.nih.gov/pubmed/35051413
http://dx.doi.org/10.1016/j.jlr.2022.100168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953623/
https://www.ncbi.nlm.nih.gov/pubmed/35051413
http://dx.doi.org/10.1016/j.jlr.2022.100168

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