Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis

Antisense oligonucleotides (ASOs) against Ldl receptor (Ldlr-ASO) represent a promising strategy to promote hypercholesterolemic atherosclerosis in animal models without the need for complex breeding strategies. Here, we sought to characterize and contrast atherosclerosis in mice given Ldlr-ASO with...

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Detalles Bibliográficos
Autores principales: Gomes, Diego, Wang, Shari, Goodspeed, Leela, Turk, Katherine E., Wietecha, Tomasz, Liu, Yongjun, Bornfeldt, Karin E., O'Brien, Kevin D., Chait, Alan, den Hartigh, Laura J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953673/
https://www.ncbi.nlm.nih.gov/pubmed/35101425
http://dx.doi.org/10.1016/j.jlr.2022.100174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953673/
https://www.ncbi.nlm.nih.gov/pubmed/35101425
http://dx.doi.org/10.1016/j.jlr.2022.100174

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