Theoretical Characterization of the Step-by-Step Mechanism of Conversion of Leukotriene A(4) to Leukotriene B(4) Catalysed by the Enzyme Leukotriene A(4) Hydrolase

LTA(4)H is a bifunctional zinc metalloenzyme that converts leukotriene A(4) (LTA(4)) into leukotriene B(4) (LTB(4)), one of the most potent chemotactic agents involved in acute and chronic inflammatory diseases. In this reaction, LTA(4)H acts as an epoxide hydrolase with a unique and fascinating mec...

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Detalles Bibliográficos
Autores principales: Canyelles-Niño, Miquel, González-Lafont, Àngels, Lluch, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954237/
https://www.ncbi.nlm.nih.gov/pubmed/35328561
http://dx.doi.org/10.3390/ijms23063140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954237/
https://www.ncbi.nlm.nih.gov/pubmed/35328561
http://dx.doi.org/10.3390/ijms23063140

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