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Theoretical Characterization of the Step-by-Step Mechanism of Conversion of Leukotriene A(4) to Leukotriene B(4) Catalysed by the Enzyme Leukotriene A(4) Hydrolase
LTA(4)H is a bifunctional zinc metalloenzyme that converts leukotriene A(4) (LTA(4)) into leukotriene B(4) (LTB(4)), one of the most potent chemotactic agents involved in acute and chronic inflammatory diseases. In this reaction, LTA(4)H acts as an epoxide hydrolase with a unique and fascinating mec...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954237/ https://www.ncbi.nlm.nih.gov/pubmed/35328561 http://dx.doi.org/10.3390/ijms23063140 |