Structural Plasticity Is a Feature of Rheostat Positions in the Human Na(+)/Taurocholate Cotransporting Polypeptide (NTCP)

In the Na(+)/taurocholate cotransporting polypeptide (NTCP), the clinically relevant S267F polymorphism occurs at a “rheostat position”. That is, amino acid substitutions at this position (“S267X”) lead to a wide range of functional outcomes. This result was particularly striking because molecular m...

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Detalles Bibliográficos
Autores principales: Ruggiero, Melissa J., Malhotra, Shipra, Fenton, Aron W., Swint-Kruse, Liskin, Karanicolas, John, Hagenbuch, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954283/
https://www.ncbi.nlm.nih.gov/pubmed/35328632
http://dx.doi.org/10.3390/ijms23063211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954283/
https://www.ncbi.nlm.nih.gov/pubmed/35328632
http://dx.doi.org/10.3390/ijms23063211

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