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Loss of Microglial Insulin Receptor Leads to Sex-Dependent Metabolic Disorders in Obese Mice
Obesity and type 2 diabetes mellitus (T2DM) are highly prevalent disorders, associated with insulin resistance and chronic inflammation. The brain is key for energy homeostasis and contains many insulin receptors. Microglia, the resident brain immune cells, are known to express insulin receptors (In...
Autores principales: | Milanova, Irina V., Korpel, Nikita L., Correa-da-Silva, Felipe, Berends, Eline, Osman, Samar, la Fleur, Susanne E., Fliers, Eric, Kalsbeek, Andries, Yi, Chun-Xia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954452/ https://www.ncbi.nlm.nih.gov/pubmed/35328354 http://dx.doi.org/10.3390/ijms23062933 |
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