Dysfunctional cGMP Signaling Leads to Age-Related Retinal Vascular Alterations and Astrocyte Remodeling in Mice

The nitric oxide–guanylyl cyclase-1–cyclic guanylate monophosphate (NO–GC-1–cGMP) pathway is integral to the control of vascular tone and morphology. Mice lacking the alpha catalytic domain of guanylate cyclase (GC1(−/−)) develop retinal ganglion cell (RGC) degeneration with age, with only modest fl...

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Detalles Bibliográficos
Autores principales: Holden, Joseph M., Al Hussein Al Awamlh, Sara, Croteau, Louis-Philippe, Boal, Andrew M., Rex, Tonia S., Risner, Michael L., Calkins, David J., Wareham, Lauren K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954518/
https://www.ncbi.nlm.nih.gov/pubmed/35328488
http://dx.doi.org/10.3390/ijms23063066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954518/
https://www.ncbi.nlm.nih.gov/pubmed/35328488
http://dx.doi.org/10.3390/ijms23063066

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