Correlating Mass Spectrometry Imaging and Liquid Chromatography-Tandem Mass Spectrometry for Tissue-Based Pharmacokinetic Studies

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a standard tool used for absolute quantification of drugs in pharmacokinetic (PK) studies. However, all spatial information is lost during the extraction and elucidation of a drugs biodistribution within the tissue is impossible. In the st...

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Detalles Bibliográficos
Autores principales: Dannhorn, Andreas, Kazanc, Emine, Hamm, Gregory, Swales, John G., Strittmatter, Nicole, Maglennon, Gareth, Goodwin, Richard J. A., Takats, Zoltan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954739/
https://www.ncbi.nlm.nih.gov/pubmed/35323705
http://dx.doi.org/10.3390/metabo12030261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954739/
https://www.ncbi.nlm.nih.gov/pubmed/35323705
http://dx.doi.org/10.3390/metabo12030261

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