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A Microphysiological Cell-Culturing System for Pharmacokinetic Drug Exposure and High-Resolution Imaging of Arrays of 3D Microtissues
Understanding the pharmacokinetic/pharmacodynamic (PK/PD)-relationship of a drug candidate is key to determine effective, yet safe treatment regimens for patients. However, current testing strategies are inefficient in characterizing in vivo responses to fluctuating drug concentrations during multi-...
Autores principales: | Lohasz, Christian, Loretan, Jacqueline, Sterker, Dario, Görlach, Ekkehard, Renggli, Kasper, Argast, Paul, Frey, Olivier, Wiesmann, Marion, Wartmann, Markus, Rausch, Martin, Hierlemann, Andreas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954798/ https://www.ncbi.nlm.nih.gov/pubmed/35342386 http://dx.doi.org/10.3389/fphar.2021.785851 |
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