Design, Synthesis, Molecular Docking, and Biological Evaluation of Pyrazole Hybrid Chalcone Conjugates as Potential Anticancer Agents and Tubulin Polymerization Inhibitors

Some (E)-3-(3-(4-(benzyloxy)phenyl)-1-phenyl-1H-pyrazol-4-yl)-1-phenylprop-2-en-1-one conjugates 5a–r were designed; synthesized; characterized by (1)H, (13)C NMR, and ESI-MS; and evaluated for tubulin polymerization inhibitory activity and in vitro cytotoxicity against breast (MCF-7), cervical (SiH...

Descripción completa

Detalles Bibliográficos
Autores principales: Alam, Md. Jahangir, Alam, Ozair, Perwez, Ahmad, Rizvi, Moshahid Alam, Naim, Mohd Javed, Naidu, Vegi G. M., Imran, Mohd, Ghoneim, Mohammed M., Alshehri, Sultan, Shakeel, Faiyaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954831/
https://www.ncbi.nlm.nih.gov/pubmed/35337078
http://dx.doi.org/10.3390/ph15030280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954831/
https://www.ncbi.nlm.nih.gov/pubmed/35337078
http://dx.doi.org/10.3390/ph15030280

Ejemplares similares