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Design, Synthesis, Molecular Docking, and Biological Evaluation of Pyrazole Hybrid Chalcone Conjugates as Potential Anticancer Agents and Tubulin Polymerization Inhibitors

Some (E)-3-(3-(4-(benzyloxy)phenyl)-1-phenyl-1H-pyrazol-4-yl)-1-phenylprop-2-en-1-one conjugates 5a–r were designed; synthesized; characterized by (1)H, (13)C NMR, and ESI-MS; and evaluated for tubulin polymerization inhibitory activity and in vitro cytotoxicity against breast (MCF-7), cervical (SiH...

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Detalles Bibliográficos
Autores principales:	Alam, Md. Jahangir, Alam, Ozair, Perwez, Ahmad, Rizvi, Moshahid Alam, Naim, Mohd Javed, Naidu, Vegi G. M., Imran, Mohd, Ghoneim, Mohammed M., Alshehri, Sultan, Shakeel, Faiyaz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954831/ https://www.ncbi.nlm.nih.gov/pubmed/35337078 http://dx.doi.org/10.3390/ph15030280

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