Biased β-Agonists Favoring Gs over β-Arrestin for Individualized Treatment of Obstructive Lung Disease

Signals from G-protein-coupled receptors (GPCRs) are the most frequently targeted pathways of currently prescribed therapeutics. Rather than being a simple switch, it is now evident that a given receptor can directly initiate multiple signals, and biasing to achieve signal selectivity based on agoni...

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Detalles Bibliográficos
Autores principales: Tokmakova, Alina, Kim, Donghwa, Goddard, William A., Liggett, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955194/
https://www.ncbi.nlm.nih.gov/pubmed/35330331
http://dx.doi.org/10.3390/jpm12030331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955194/
https://www.ncbi.nlm.nih.gov/pubmed/35330331
http://dx.doi.org/10.3390/jpm12030331

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