New Applications of JAK/STAT Inhibitors in Pediatrics: Current Use of Ruxolitinib

Janus kinases (JAK) are a family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) that transduce cytokine-mediated signals through the JAK–STAT metabolic pathway. These kinases act by regulating the transcription of specific genes capable of inducing biological responses in several immune cell subse...

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Detalles Bibliográficos
Autores principales: Marcuzzi, Annalisa, Rimondi, Erika, Melloni, Elisabetta, Gonelli, Arianna, Grasso, Antonio Giacomo, Barbi, Egidio, Maximova, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955311/
https://www.ncbi.nlm.nih.gov/pubmed/35337171
http://dx.doi.org/10.3390/ph15030374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955311/
https://www.ncbi.nlm.nih.gov/pubmed/35337171
http://dx.doi.org/10.3390/ph15030374

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