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CRISPR/Cas9-Based Mutagenesis of Histone H3.1 in Spinal Dynorphinergic Neurons Attenuates Thermal Sensitivity in Mice

Burn injury is a trauma resulting in tissue degradation and severe pain, which is processed first by neuronal circuits in the spinal dorsal horn. We have recently shown that in mice, excitatory dynorphinergic (Pdyn) neurons play a pivotal role in the response to burn-injury-associated tissue damage...

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Detalles Bibliográficos
Autores principales: Mészár, Zoltán, Kókai, Éva, Varga, Rita, Ducza, László, Papp, Tamás, Béresová, Monika, Nagy, Marianna, Szücs, Péter, Varga, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955318/
https://www.ncbi.nlm.nih.gov/pubmed/35328599
http://dx.doi.org/10.3390/ijms23063178