Cargando…

Preclinical Evaluation of CAR T Cell Function: In Vitro and In Vivo Models

Immunotherapy using chimeric antigen receptor (CAR) T cells is a rapidly emerging modality that engineers T cells to redirect tumor-specific cytotoxicity. CAR T cells have been well characterized for their efficacy against B cell malignancies, and rigorously studied in other types of tumors. Preclin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Si, Xiaohui, Xiao, Lu, Brown, Christine E., Wang, Dongrui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955360/ https://www.ncbi.nlm.nih.gov/pubmed/35328572 http://dx.doi.org/10.3390/ijms23063154

Ejemplares similares

Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings
por: Li, Runpeng, et al.
Publicado: (2023)

Humanized Mice Are Precious Tools for Preclinical Evaluation of CAR T and CAR NK Cell Therapies
por: Mhaidly, Rana, et al.
Publicado: (2020)

CAR T cells for brain tumors: Lessons learned and road ahead
por: Akhavan, David, et al.
Publicado: (2019)

A Preclinical Embryonic Zebrafish Xenograft Model to Investigate CAR T Cells in Vivo
por: Pascoal, Susana, et al.
Publicado: (2020)

Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells
por: Huang, Yue, et al.
Publicado: (2022)

Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering
por: Michels, Kathryn R, et al.
Publicado: (2023)

CAR models: next-generation CAR modifications for enhanced T-cell function
por: Abate-Daga, Daniel, et al.
Publicado: (2016)

In vitro evaluation of CAR-T cells in patient-derived glioblastoma models
por: Brakel, Benjamin A., et al.
Publicado: (2021)

Ex vivo Bone Models and Their Potential in Preclinical Evaluation
por: Cramer, E. E. A., et al.
Publicado: (2021)

Preclinical Testing of CAR T Cells in a Patient-Derived Xenograft Model of Glioblastoma
por: Tatari, Nazanin, et al.
Publicado: (2020)

Pancreatic Ductal Adenocarcinoma: Preclinical in vitro and ex vivo Models
por: Gündel, Beate, et al.
Publicado: (2021)

Preclinical evaluation of CD70-specific CAR T cells targeting acute myeloid leukemia
por: Wu, Gongqiang, et al.
Publicado: (2023)

Preclinical evaluation and structural optimization of anti-BCMA CAR to target multiple myeloma
por: Harush, Ortal, et al.
Publicado: (2022)

High-dimensional functional phenotyping of preclinical human CAR T cells using mass cytometry
por: Michelozzi, Ilaria M., et al.
Publicado: (2022)

CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing
por: Andersch, Lena, et al.
Publicado: (2019)

IL-23 and PSMA-targeted duo-CAR T cells in Prostate Cancer Eradication in a preclinical model
por: Wang, Dawei, et al.
Publicado: (2020)

Preclinical and clinical studies of CAR-NK-cell therapies for malignancies
por: Li, Hongwen, et al.
Publicado: (2022)

PSMA-Specific CAR-Engineered T Cells Eradicate Disseminated Prostate Cancer in Preclinical Models
por: Zuccolotto, Gaia, et al.
Publicado: (2014)

Preclinical In Vivo Modeling of Pediatric Sarcoma—Promises and Limitations
por: Imle, Roland, et al.
Publicado: (2021)

Preclinical efficacy and safety evaluation of interleukin-6-knockdown CAR-T cells targeting at CD19
por: Wen, Hairuo, et al.
Publicado: (2021)

Mechanisms of immune effector cell‐associated neurotoxicity syndrome after CAR‐T treatment
por: Gu, Tianning, et al.
Publicado: (2022)

Gallic acid enhances anti-lymphoma function of anti-CD19 CAR-T cells in vitro and in vivo
por: Luo, Zhiqiang, et al.
Publicado: (2023)

Preclinical study of diabetic foot ulcers: From pathogenesis to vivo/vitro models and clinical therapeutic transformation
por: Du, Yuqing, et al.
Publicado: (2023)

In Vitro-Transcribed mRNA Chimeric Antigen Receptor T Cell (IVT mRNA CAR T) Therapy in Hematologic and Solid Tumor Management: A Preclinical Update
por: Soundara Rajan, Thangavelu, et al.
Publicado: (2020)

HDAC inhibitor valproic acid upregulates CAR in vitro and in vivo
por: Segura-Pacheco, Blanca, et al.
Publicado: (2007)

Preclinical Evidence of the Efficacy of Lewis Y Car T Cells in Patient-Derived Models of Prostate Cancer
por: Risbridger, Gail Petuna, et al.
Publicado: (2021)

Constitutive Turbodomains enhance expansion and antitumor activity of allogeneic BCMA CAR T cells in preclinical models
por: Lin, Regina J., et al.
Publicado: (2023)

Next frontiers in CAR T-cell therapy
por: Brown, Christine E, et al.
Publicado: (2016)

CARTmath—A Mathematical Model of CAR-T Immunotherapy in Preclinical Studies of Hematological Cancers
por: Barros, Luciana R. C., et al.
Publicado: (2021)

Preclinical development of CD126 CAR-T cells with broad antitumor activity
por: Mishra, Ameet K., et al.
Publicado: (2021)

Preclinical In Vivo-Models to Investigate HIPEC; Current Methodologies and Challenges
por: Helderman, Roxan F. C. P. A., et al.
Publicado: (2021)

Outsmarting trogocytosis to boost CAR NK/T cell therapy
por: Ramezani, Faezeh, et al.
Publicado: (2023)

Synergistic effect of ibrutinib and CD19 CAR‐T cells on Raji cells in vivo and in vitro
por: Liu, Meijing, et al.
Publicado: (2020)

Preclinical evaluation of CD8+ anti-BCMA mRNA CAR T-cells for treatment of multiple myeloma
por: Lin, Liang, et al.
Publicado: (2020)

Preclinical Study of Antineoplastic Sinoporphyrin Sodium-PDT via In Vitro and In Vivo Models
por: Shi, Rui, et al.
Publicado: (2017)

Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models
por: Nono, Justin Komguep, et al.
Publicado: (2020)

CAR-Macrophages and CAR-T Cells Synergistically Kill Tumor Cells In Vitro
por: Liu, Maoxuan, et al.
Publicado: (2022)

In Vitro and In Vivo Models for Evaluating the Oral Toxicity of Nanomedicines
por: Lama, Sudeep, et al.
Publicado: (2020)

In vivo molecular imaging in preclinical research
por: Kim, Su Jin, et al.
Publicado: (2022)

Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies
por: Lu, Yingjuan J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_hp95t5tq3pdae9q7fhm7010u4b