Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays

Cystic fibrosis (CF) is a genetic disease affecting the lungs and pancreas and causing progressive damage. CF is caused by mutations abolishing the function of CFTR, a protein whose role is chloride’s mobilization in the epithelial cells of various organs. Recently a therapy focused on small molecul...

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Detalles Bibliográficos
Autores principales: Parodi, Alice, Righetti, Giada, Pesce, Emanuela, Salis, Annalisa, Tomati, Valeria, Pastorino, Cristina, Tasso, Bruno, Benvenuti, Mirko, Damonte, Gianluca, Pedemonte, Nicoletta, Cichero, Elena, Millo, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955485/
https://www.ncbi.nlm.nih.gov/pubmed/35337072
http://dx.doi.org/10.3390/ph15030274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955485/
https://www.ncbi.nlm.nih.gov/pubmed/35337072
http://dx.doi.org/10.3390/ph15030274

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