Dual-Function Semaphorin 4D Released by Platelets: Suppression of Osteoblastogenesis and Promotion of Osteoclastogenesis

Effects of the antiosteoblastogenesis factor Semaphorin 4D (Sema4D), expressed by thrombin-activated platelets (TPs), on osteoblastogenesis, as well as osteoclastogenesis, were investigated in vitro. Intact platelets released both Sema4D and IGF-1. However, in response to stimulation with thrombin,...

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Detalles Bibliográficos
Autores principales: Shindo, Satoru, Savitri, Irma Josefina, Ishii, Takenobu, Ikeda, Atsushi, Pierrelus, Roodelyne, Heidari, Alireza, Okubo, Keisuke, Nakamura, Shin, Kandalam, Umadevi, Rawas-Qalaji, Mohamad, Leon, Elizabeth, Pastore, Maria Rita, Hardigan, Patrick, Kawai, Toshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955605/
https://www.ncbi.nlm.nih.gov/pubmed/35328359
http://dx.doi.org/10.3390/ijms23062938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955605/
https://www.ncbi.nlm.nih.gov/pubmed/35328359
http://dx.doi.org/10.3390/ijms23062938

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