Metformin Enhances TKI-Afatinib Cytotoxic Effect, Causing Downregulation of Glycolysis, Epithelial–Mesenchymal Transition, and EGFR-Signaling Pathway Activation in Lung Cancer Cells

The combination of metformin and TKIs for non-small cell lung cancer has been proposed as a strategy to overcome resistance of neoplastic cells induced by several molecular mechanisms. This study sought to investigate the effects of a second generation TKI afatinib, metformin, or their combination o...

Descripción completa

Detalles Bibliográficos
Autores principales: Barrios-Bernal, Pedro, Hernandez-Pedro, Norma, Orozco-Morales, Mario, Viedma-Rodríguez, Rubí, Lucio-Lozada, José, Avila-Moreno, Federico, Cardona, Andrés F., Rosell, Rafael, Arrieta, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955777/
https://www.ncbi.nlm.nih.gov/pubmed/35337178
http://dx.doi.org/10.3390/ph15030381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955777/
https://www.ncbi.nlm.nih.gov/pubmed/35337178
http://dx.doi.org/10.3390/ph15030381

Ejemplares similares