Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies

Conventional approaches to isolate and characterize nanobodies are laborious. We combine phage display, multivariate enrichment, next-generation sequencing, and a streamlined screening strategy to identify numerous anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nanobodies. We char...

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Detalles Bibliográficos
Autores principales: Hanke, Leo, Sheward, Daniel J., Pankow, Alec, Vidakovics, Laura Perez, Karl, Vivien, Kim, Changil, Urgard, Egon, Smith, Natalie L., Astorga-Wells, Juan, Ekström, Simon, Coquet, Jonathan M., McInerney, Gerald M., Murrell, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956255/
https://www.ncbi.nlm.nih.gov/pubmed/35333580
http://dx.doi.org/10.1126/sciadv.abm0220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956255/
https://www.ncbi.nlm.nih.gov/pubmed/35333580
http://dx.doi.org/10.1126/sciadv.abm0220

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