pH regulates potassium conductance and drives a constitutive proton current in human TMEM175

Human TMEM175, a noncanonical potassium (K(+)) channel in endolysosomes, contributes to their pH stability and is implicated in the pathogenesis of Parkinson’s disease (PD). Structurally, the TMEM175 family exhibits an architecture distinct from canonical potassium channels, as it lacks the typical...

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Detalles Bibliográficos
Autores principales: Zheng, Wang, Shen, Chen, Wang, Longfei, Rawson, Shaun, Xie, Wen Jun, Nist-Lund, Carl, Wu, Jason, Shen, Zhangfei, Xia, Shiyu, Holt, Jeffrey R., Wu, Hao, Fu, Tian-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956256/
https://www.ncbi.nlm.nih.gov/pubmed/35333573
http://dx.doi.org/10.1126/sciadv.abm1568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956256/
https://www.ncbi.nlm.nih.gov/pubmed/35333573
http://dx.doi.org/10.1126/sciadv.abm1568

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