Cargando…

pH regulates potassium conductance and drives a constitutive proton current in human TMEM175

Human TMEM175, a noncanonical potassium (K(+)) channel in endolysosomes, contributes to their pH stability and is implicated in the pathogenesis of Parkinson’s disease (PD). Structurally, the TMEM175 family exhibits an architecture distinct from canonical potassium channels, as it lacks the typical...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Wang, Shen, Chen, Wang, Longfei, Rawson, Shaun, Xie, Wen Jun, Nist-Lund, Carl, Wu, Jason, Shen, Zhangfei, Xia, Shiyu, Holt, Jeffrey R., Wu, Hao, Fu, Tian-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956256/ https://www.ncbi.nlm.nih.gov/pubmed/35333573 http://dx.doi.org/10.1126/sciadv.abm1568

Ejemplares similares

The Lysosomal Potassium Channel TMEM175 Adopts a Novel Tetrameric Architecture
por: Lee, Changkeun, et al.
Publicado: (2017)

Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds
por: Pergel, Enikő, et al.
Publicado: (2021)

The minimal intrinsic stochasticity of constitutively expressed eukaryotic genes is sub-Poissonian
por: Weidemann, Douglas E., et al.
Publicado: (2023)

Constitutive Turbodomains enhance expansion and antitumor activity of allogeneic BCMA CAR T cells in preclinical models
por: Lin, Regina J., et al.
Publicado: (2023)

Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation
por: Tapia-Abellán, Ana, et al.
Publicado: (2021)

A gating lever and molecular logic gate that couple voltage and calcium sensor activation to opening in BK potassium channels
por: Sun, Liang, et al.
Publicado: (2022)

Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1
por: Pihán, Philippe, et al.
Publicado: (2021)

Control of infection by LC3-associated phagocytosis, CASM, and detection of raised vacuolar pH by the V-ATPase-ATG16L1 axis
por: Wang, Yingxue, et al.
Publicado: (2022)

Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis
por: Wu, Yizheng, et al.
Publicado: (2023)

The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels
por: Coonen, Laura, et al.
Publicado: (2022)

Regulation of PD-L1 through direct binding of cholesterol to CRAC motifs
por: Wang, Qian, et al.
Publicado: (2022)

Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs
por: Wu, Xiaotong, et al.
Publicado: (2021)

Comprehensive analysis of spatial architecture in primary liver cancer
por: Wu, Rui, et al.
Publicado: (2021)

Iron deficiency–induced ferritinophagy impairs skeletal muscle regeneration through RNF20-mediated H2Bub1 modification
por: Che, Yunshu, et al.
Publicado: (2023)

TEAD4 is a master regulator of high-risk nasopharyngeal carcinoma
por: Wang, Ya-Qin, et al.
Publicado: (2023)

Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis
por: Ma, Longfei, et al.
Publicado: (2022)

Structure of a diatom photosystem II supercomplex containing a member of Lhcx family and dimeric FCPII
por: Feng, Yue, et al.
Publicado: (2023)

TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion
por: Zhang, Mengling, et al.
Publicado: (2020)

N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system
por: Jiang, Feng, et al.
Publicado: (2022)

PABPN1 functions as a hub in the assembly of nuclear poly(A) domains that are essential for mouse oocyte development
por: Dai, Xing-Xing, et al.
Publicado: (2022)

Structural insight into UV-B–activated UVR8 bound to COP1
por: Wang, Yidong, et al.
Publicado: (2022)

Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model
por: Zhu, Jinjin, et al.
Publicado: (2022)

Lipid-anchored proteasomes control membrane protein homeostasis
por: Zhang, Ruizhu, et al.
Publicado: (2023)

Structure of the human Meckel-Gruber protein Meckelin
por: Liu, Dongliang, et al.
Publicado: (2021)

Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant
por: Li, Yaning, et al.
Publicado: (2023)

MAPK6-AKT signaling promotes tumor growth and resistance to mTOR kinase blockade
por: Cai, Qinbo, et al.
Publicado: (2021)

Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis
por: Lei, Yiting, et al.
Publicado: (2022)

High-specificity protection against radiation-induced bone loss by a pulsed electromagnetic field
por: Yan, Zedong, et al.
Publicado: (2022)

Structural basis for ion selectivity in TMEM175 K(+) channels
por: Brunner, Janine D, et al.
Publicado: (2020)

Gating and selectivity mechanisms for the lysosomal K(+) channel TMEM175
por: Oh, SeCheol, et al.
Publicado: (2020)

Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175
por: Oh, SeCheol, et al.
Publicado: (2022)

A lysosomal regulatory circuit essential for the development and function of microglia
por: Iyer, Harini, et al.
Publicado: (2022)

Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module
por: Wang, Shifeng, et al.
Publicado: (2023)

Single-cell transcriptome of early hematopoiesis guides arterial endothelial-enhanced functional T cell generation from human PSCs
por: Shen, Jun, et al.
Publicado: (2021)

The cryo-EM structure of the human ERAD retrotranslocation complex
por: Rao, Bing, et al.
Publicado: (2023)

Expansion microscopy with ninefold swelling (NIFS) hydrogel permits cellular ultrastructure imaging on conventional microscope
por: Li, Hongxia, et al.
Publicado: (2022)

Single-virus tracking reveals variant SARS-CoV-2 spike proteins induce ACE2-independent membrane interactions
por: Christie, Shaun M., et al.
Publicado: (2022)

Dual activities of ACC synthase: Novel clues regarding the molecular evolution of ACS genes
por: Xu, Chang, et al.
Publicado: (2021)

Injectable photocurable Janus hydrogel delivering hiPSC cardiomyocyte-derived exosome for post–heart surgery adhesion reduction
por: Wang, Ling, et al.
Publicado: (2023)

Intracellular delivery of nitric oxide enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction
por: Hao, Tian, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fen5mml007dghorveltqmb6t5a