PBLD inhibits angiogenesis via impeding VEGF/VEGFR2-mediated microenvironmental cross-talk between HCC cells and endothelial cells

Sustained anti-angiogenesis therapy increases the level of tumor hypoxia, leading to increased expression of HIF-1a, thereby contributing to the resistance to anti-angiogenesis therapy in hepatocellular carcinoma (HCC). Here, we report that phenazine biosynthesis-like domain-containing protein (PBLD...

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Detalles Bibliográficos
Autores principales: Han, Lu, Lin, Xin, Yan, Qun, Gu, Chuncai, Li, Mengshu, Pan, Lei, Meng, Yan, Zhao, Xinmei, Liu, Side, Li, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956508/
https://www.ncbi.nlm.nih.gov/pubmed/35140333
http://dx.doi.org/10.1038/s41388-022-02197-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956508/
https://www.ncbi.nlm.nih.gov/pubmed/35140333
http://dx.doi.org/10.1038/s41388-022-02197-x

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