Crystal structure of progeria mutant S143F lamin A/C reveals increased hydrophobicity driving nuclear deformation

Lamins are intermediate filaments that form a 3-D meshwork in the periphery of the nuclear envelope. The recent crystal structure of a long fragment of human lamin A/C visualized the tetrameric assembly unit of the central rod domain as a polymerization intermediate. A genetic mutation of S143F caus...

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Detalles Bibliográficos
Autores principales: Ahn, Jinsook, Jeong, Soyeon, Kang, So-mi, Jo, Inseong, Park, Bum-Joon, Ha, Nam-Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956589/
https://www.ncbi.nlm.nih.gov/pubmed/35338226
http://dx.doi.org/10.1038/s42003-022-03212-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956589/
https://www.ncbi.nlm.nih.gov/pubmed/35338226
http://dx.doi.org/10.1038/s42003-022-03212-3

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