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Guide RNAs containing universal bases enable Cas9/Cas12a recognition of polymorphic sequences
CRISPR/Cas complexes enable precise gene editing in a wide variety of organisms. While the rigid identification of DNA sequences by these systems minimizes the potential for off-target effects, it consequently poses a problem for the recognition of sequences containing naturally occurring polymorphi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956631/ https://www.ncbi.nlm.nih.gov/pubmed/35338140 http://dx.doi.org/10.1038/s41467-022-29202-x |