MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity

The MERS coronavirus (MERS-CoV) is a highly pathogenic, emerging virus that produces accessory proteins to antagonize the host innate immune response. The MERS-CoV ORF4b protein has been shown to bind preferentially to the nuclear import adapter IMPα3 in infected cells, thereby inhibiting NF-κB-depe...

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Detalles Bibliográficos
Autores principales: Munasinghe, Thilini S., Edwards, Megan R., Tsimbalyuk, Sofiya, Vogel, Olivia A., Smith, Kate M., Stewart, Murray, Foster, Justin K., Bosence, Loretta A., Aragão, David, Roby, Justin A., Basler, Christopher F., Forwood, Jade K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956657/
https://www.ncbi.nlm.nih.gov/pubmed/35338144
http://dx.doi.org/10.1038/s41467-022-28851-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956657/
https://www.ncbi.nlm.nih.gov/pubmed/35338144
http://dx.doi.org/10.1038/s41467-022-28851-2

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