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MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity
The MERS coronavirus (MERS-CoV) is a highly pathogenic, emerging virus that produces accessory proteins to antagonize the host innate immune response. The MERS-CoV ORF4b protein has been shown to bind preferentially to the nuclear import adapter IMPα3 in infected cells, thereby inhibiting NF-κB-depe...
Autores principales: | Munasinghe, Thilini S., Edwards, Megan R., Tsimbalyuk, Sofiya, Vogel, Olivia A., Smith, Kate M., Stewart, Murray, Foster, Justin K., Bosence, Loretta A., Aragão, David, Roby, Justin A., Basler, Christopher F., Forwood, Jade K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956657/ https://www.ncbi.nlm.nih.gov/pubmed/35338144 http://dx.doi.org/10.1038/s41467-022-28851-2 |
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