Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration

BACKGROUND: Glycogen synthase kinase-3β (GSK-3β) is one of the most effective kinases in promoting tau hyperphosphorylation and accumulation in Alzheimer's disease (AD). However, it is not clear how GSK-3β activity is regulated during AD progression. METHODS: We firstly used mass spectrometry t...

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Detalles Bibliográficos
Autores principales: Zhou, Qiuzhi, Li, Shihong, Li, Mengzhu, Ke, Dan, Wang, Qun, Yang, Ying, Liu, Gong-Ping, Wang, Xiao-Chuan, Liu, Enjie, Wang, Jian-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956943/
https://www.ncbi.nlm.nih.gov/pubmed/35339896
http://dx.doi.org/10.1016/j.ebiom.2022.103970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956943/
https://www.ncbi.nlm.nih.gov/pubmed/35339896
http://dx.doi.org/10.1016/j.ebiom.2022.103970

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