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Structure-guided affinity maturation of a single-chain variable fragment antibody against the Fu-bc epitope of the dengue virus envelope protein

Dengue is one of the most dominant arthropod-borne viral diseases, infecting at least 390 million people every year throughout the world. Despite this, there is no effective treatment against dengue, and the only available vaccine has already been withdrawn owing to the significant adverse effects....

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Detalles Bibliográficos
Autores principales: Sarker, Animesh, Rathore, Abhishek Singh, Khalid, Md Fahim, Gupta, Rinkoo Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956951/
https://www.ncbi.nlm.nih.gov/pubmed/35218775
http://dx.doi.org/10.1016/j.jbc.2022.101772