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Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection
Subtilase cytotoxin (SubAB) is an AB(5) toxin mainly produced by the locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli (STEC) strain such as O113:H21, yet the contribution of SubAB to STEC infectious disease is unclear. We found that SubAB reduced activation of the STEC O113:H...
Autores principales: | Tsutsuki, Hiroyasu, Zhang, Tianli, Yahiro, Kinnosuke, Ono, Katsuhiko, Fujiwara, Yukio, Iyoda, Sunao, Wei, Fan-Yan, Monde, Kazuaki, Seto, Kazuko, Ohnishi, Makoto, Oshiumi, Hiroyuki, Akaike, Takaaki, Sawa, Tomohiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957020/ https://www.ncbi.nlm.nih.gov/pubmed/35345462 http://dx.doi.org/10.1016/j.isci.2022.104050 |
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