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Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway

BACKGROUND: Propofol and dexmedetomidine (DEX) are widely used in general anesthesia, and exert toxic and protective effects on hippocampal neurons, respectively. The study sought to investigate the molecular mechanisms of DEX-mediated neuroprotection against propofol-induced hippocampal neuron inju...

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Detalles Bibliográficos
Autores principales: Chen, Zong, Ding, Yong, Zeng, Ying, Zhang, Xue-Ping, Chen, Jian-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957152/
https://www.ncbi.nlm.nih.gov/pubmed/35337381
http://dx.doi.org/10.1186/s40360-022-00555-9