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Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods
This commentary compares 233 CheqSol intrinsic solubility values (log S(0)) reported in the Wiki-pS(0) database for 145 different druglike molecules to the 838 log S(0) values determined mostly by the saturation shake-flask (SSF) method for 124 of the molecules from the CheqSol set. The range of log...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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International Association of Physical Chemists
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957238/ https://www.ncbi.nlm.nih.gov/pubmed/35350660 http://dx.doi.org/10.5599/admet.698 |