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Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods

This commentary compares 233 CheqSol intrinsic solubility values (log S(0)) reported in the Wiki-pS(0) database for 145 different druglike molecules to the 838 log S(0) values determined mostly by the saturation shake-flask (SSF) method for 124 of the molecules from the CheqSol set. The range of log...

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Detalles Bibliográficos
Autor principal: Avdeef, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Association of Physical Chemists 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957238/
https://www.ncbi.nlm.nih.gov/pubmed/35350660
http://dx.doi.org/10.5599/admet.698