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Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods

This commentary compares 233 CheqSol intrinsic solubility values (log S(0)) reported in the Wiki-pS(0) database for 145 different druglike molecules to the 838 log S(0) values determined mostly by the saturation shake-flask (SSF) method for 124 of the molecules from the CheqSol set. The range of log...

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Detalles Bibliográficos
Autor principal:	Avdeef, Alex
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Association of Physical Chemists 2019
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957238/ https://www.ncbi.nlm.nih.gov/pubmed/35350660 http://dx.doi.org/10.5599/admet.698

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