A physiologically-based pharmacokinetic model of oseltamivir phosphate and its carboxylate metabolite for rats and humans

Oseltamivir phosphate (OP, Tamiflu®) is a widely used prodrug for the treatment of influenza viral infections. Orally administered OP is rapidly hydrolyzed by the carboxylesterases in animals to oseltamivir carboxylate (OC), a potent influenza virus neuraminidase inhibitor. The goals of this study w...

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Detalles Bibliográficos
Autores principales: Gao, Guanghua, Law, Francis, Wong, Ricky Ngok Shun, Mak, Nai Ki, Yang, Mildred Sze Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Association of Physical Chemists 2019
Materias:
Original Scientific Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957250/
https://www.ncbi.nlm.nih.gov/pubmed/35350745
http://dx.doi.org/10.5599/admet.628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957250/
https://www.ncbi.nlm.nih.gov/pubmed/35350745
http://dx.doi.org/10.5599/admet.628

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