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A physiologically-based pharmacokinetic model of oseltamivir phosphate and its carboxylate metabolite for rats and humans

Oseltamivir phosphate (OP, Tamiflu®) is a widely used prodrug for the treatment of influenza viral infections. Orally administered OP is rapidly hydrolyzed by the carboxylesterases in animals to oseltamivir carboxylate (OC), a potent influenza virus neuraminidase inhibitor. The goals of this study w...

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Detalles Bibliográficos
Autores principales:	Gao, Guanghua, Law, Francis, Wong, Ricky Ngok Shun, Mak, Nai Ki, Yang, Mildred Sze Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Association of Physical Chemists 2019
Materias:	Original Scientific Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957250/ https://www.ncbi.nlm.nih.gov/pubmed/35350745 http://dx.doi.org/10.5599/admet.628

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