The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin

The most widely used formalin test to screen antinociceptive drug candidates is still apostrophized as targeting inflammatory pain, in spite of strong opposing evidence published. In our rat skin‐nerve preparation ex vivo, recording from all classes of sensory single‐fibers (n = 32), 30 units were t...

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Detalles Bibliográficos
Autores principales: Hoffmann, Tal, Klemm, Florian, I Kichko, Tatjana, Sauer, Susanne K, Kistner, Katrin, Riedl, Bernhard, Raboisson, Patrick, Luo, Lei, Babes, Alexandru, Kocher, Laurence, Carli, Giancarlo, Fischer, Michael J. M., Reeh, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957662/
https://www.ncbi.nlm.nih.gov/pubmed/35340127
http://dx.doi.org/10.14814/phy2.15194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957662/
https://www.ncbi.nlm.nih.gov/pubmed/35340127
http://dx.doi.org/10.14814/phy2.15194

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