Polygenic Risk Score Effectively Predicts Depression Onset in Alzheimer’s Disease Based on Major Depressive Disorder Risk Variants

INTRODUCTION: Depression is a common, though heterogenous, comorbidity in late-onset Alzheimer’s Disease (LOAD) patients. In addition, individuals with depression are at greater risk to develop LOAD. In previous work, we demonstrated shared genetic etiology between depression and LOAD. Collectively,...

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Detalles Bibliográficos
Autores principales: Upadhya, Suraj, Liu, Hongliang, Luo, Sheng, Lutz, Michael W., Chiba-Falek, Ornit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957806/
https://www.ncbi.nlm.nih.gov/pubmed/35350557
http://dx.doi.org/10.3389/fnins.2022.827447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957806/
https://www.ncbi.nlm.nih.gov/pubmed/35350557
http://dx.doi.org/10.3389/fnins.2022.827447

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