Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice

Votucalis is a biologically active protein in tick (R. appendiculatus) saliva, which specifically binds histamine with high affinity and, therefore, has the potential to inhibit the host’s immunological responses at the feeding site. We hypothesized that scavenging of peripherally released endogenou...

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Detalles Bibliográficos
Autores principales: Alrashdi, Ibrahim, Alsubaiyel, Amal, Chan, Michele, Battell, Emma E., Ennaceur, Abdel, Nunn, Miles A., Weston-Davies, Wayne, Chazot, Paul L., Obara, Ilona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957863/
https://www.ncbi.nlm.nih.gov/pubmed/35350753
http://dx.doi.org/10.3389/fphar.2022.846683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957863/
https://www.ncbi.nlm.nih.gov/pubmed/35350753
http://dx.doi.org/10.3389/fphar.2022.846683

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