Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets

Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and eosinophil trafficking. IL-13 cooperates with IL-4 in promoting IgE synthesis, and also induces nitric oxide (...

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Detalles Bibliográficos
Autores principales: Pelaia, Corrado, Heffler, Enrico, Crimi, Claudia, Maglio, Angelantonio, Vatrella, Alessandro, Pelaia, Girolamo, Canonica, Giorgio Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957960/
https://www.ncbi.nlm.nih.gov/pubmed/35350765
http://dx.doi.org/10.3389/fphar.2022.851940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957960/
https://www.ncbi.nlm.nih.gov/pubmed/35350765
http://dx.doi.org/10.3389/fphar.2022.851940

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