Cargando…
Antibody-Mediated Inhibition of Insulin-Degrading Enzyme Improves Insulin Activity in a Diabetic Mouse Model
Diabetes is a metabolic disease that may lead to different life-threatening complications. While insulin constitutes a beneficial treatment, its use may be limited due to increased degradation and an increase in side effects such as weight gain and hypoglycemia. Small molecule inhibitors to insulin-...
Autores principales: | Fursht, Ofir, Liran, Mirit, Nash, Yuval, Medala, Vijay Krishna, Ini, Dor, Royal, Tabitha Grace, Goldsmith, Guy, Nahary, Limor, Benhar, Itai, Frenkel, Dan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958001/ https://www.ncbi.nlm.nih.gov/pubmed/35350789 http://dx.doi.org/10.3389/fimmu.2022.835774 |
Ejemplares similares
-
MON-LB031 Higher Insulin Degrading Enzyme Levels in Subjects with Metabolic Syndrome
por: Sofer, Yael, et al.
Publicado: (2019) -
Engineered Toxins “Zymoxins” Are Activated by the HCV NS3 Protease by Removal of an Inhibitory Protein Domain
por: Shapira, Assaf, et al.
Publicado: (2011) -
Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model
por: Chen, Wenqiang, et al.
Publicado: (2023) -
Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival
por: Malakar, Pushkar, et al.
Publicado: (2016) -
Redox Regulation of Insulin Degradation by Insulin-Degrading Enzyme
por: Cordes, Crystal M., et al.
Publicado: (2011)