Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice

The large number of spike substitutions in Omicron lineage variants (BA.1, BA.1.1., and BA.2) could jeopardize the efficacy of SARS-CoV-2 vaccines. We evaluated in mice the protective efficacy of the Moderna mRNA-1273 vaccine against BA.1 before or after boosting. Whereas two doses of mRNA-1273 vacc...

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Detalles Bibliográficos
Autores principales: Ying, Baoling, Scheaffer, Suzanne M., Whitener, Bradley, Liang, Chieh-Yu, Dmytrenko, Oleksandr, Mackin, Samantha, Wu, Kai, Lee, Diana, Avena, Laura E., Chong, Zhenlu, Case, James Brett, Ma, LingZhi, Kim, Thu T.M., Sein, Caralyn E., Woods, Angela, Berrueta, Daniela Montes, Chang, Gwo-Yu, Stewart-Jones, Guillaume, Renzi, Isabella, Lai, Yen-Ting, Malinowski, Agata, Carfi, Andrea, Elbashir, Sayda M., Edwards, Darin K., Thackray, Larissa B., Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958157/
https://www.ncbi.nlm.nih.gov/pubmed/35452622
http://dx.doi.org/10.1016/j.cell.2022.03.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958157/
https://www.ncbi.nlm.nih.gov/pubmed/35452622
http://dx.doi.org/10.1016/j.cell.2022.03.037

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