FRET sensors reveal the retinal entry pathway in the G protein-coupled receptor rhodopsin

The photoreceptor rhodopsin (Rho) becomes active when a tethered inverse agonist ligand (11CR) is photoconverted to an agonist (ATR). The ligand-binding pocket of inactive rhodopsin is completely enclosed, whereas active rhodopsin displays pores accessible from the lipid bilayer. Stabilization of ac...

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Detalles Bibliográficos
Autores principales: Tian, He, Gunnison, Kathryn M., Kazmi, Manija A., Sakmar, Thomas P., Huber, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958324/
https://www.ncbi.nlm.nih.gov/pubmed/35355518
http://dx.doi.org/10.1016/j.isci.2022.104060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958324/
https://www.ncbi.nlm.nih.gov/pubmed/35355518
http://dx.doi.org/10.1016/j.isci.2022.104060

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