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FRET sensors reveal the retinal entry pathway in the G protein-coupled receptor rhodopsin

The photoreceptor rhodopsin (Rho) becomes active when a tethered inverse agonist ligand (11CR) is photoconverted to an agonist (ATR). The ligand-binding pocket of inactive rhodopsin is completely enclosed, whereas active rhodopsin displays pores accessible from the lipid bilayer. Stabilization of ac...

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Detalles Bibliográficos
Autores principales:	Tian, He, Gunnison, Kathryn M., Kazmi, Manija A., Sakmar, Thomas P., Huber, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958324/ https://www.ncbi.nlm.nih.gov/pubmed/35355518 http://dx.doi.org/10.1016/j.isci.2022.104060

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