A series of xanthenes inhibiting Rad6 function and Rad6-Rad18 interaction in the PCNA ubiquitination cascade

Ubiquitination of proliferating cell nuclear antigen (PCNA) triggers pathways of DNA damage tolerance, including mutagenic translesion DNA synthesis, and comprises a cascade of reactions involving the E1 ubiquitin-activating enzyme Uba1, the E2 ubiquitin-conjugating enzyme Rad6, and the E3 ubiquitin...

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Detalles Bibliográficos
Autores principales: Fenteany, Gabriel, Sharma, Gaurav, Gaur, Paras, Borics, Attila, Wéber, Edit, Kiss, Ernő, Haracska, Lajos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958325/
https://www.ncbi.nlm.nih.gov/pubmed/35355521
http://dx.doi.org/10.1016/j.isci.2022.104053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958325/
https://www.ncbi.nlm.nih.gov/pubmed/35355521
http://dx.doi.org/10.1016/j.isci.2022.104053

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