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Dynamic Combinatorial Optimization of In Vitro and In Vivo Heparin Antidotes
[Image: see text] Heparin-like macromolecules are widely used in clinics as anticoagulant, antiviral, and anticancer drugs. However, the search of heparin antidotes based on small synthetic molecules to control blood coagulation still remains a challenging task due to the physicochemical properties...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958503/ https://www.ncbi.nlm.nih.gov/pubmed/35235323 http://dx.doi.org/10.1021/acs.jmedchem.1c02054 |