Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades

[Image: see text] By replacing a phenolic ring of (E)-resveratrol with an 1,3,4-oxadiazol-2(3H)-one heterocycle, new resveratrol-based multitarget-directed ligands (MTDLs) were obtained. They were evaluated in several assays related to oxidative stress and inflammation (monoamine oxidases, nuclear e...

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Detalles Bibliográficos
Autores principales: Herrera-Arozamena, Clara, Estrada-Valencia, Martín, López-Caballero, Patricia, Pérez, Concepción, Morales-García, José A., Pérez-Castillo, Ana, Sastre, Eric del, Fernández-Mendívil, Cristina, Duarte, Pablo, Michalska, Patrycja, Lombardía, José, Senar, Sergio, León, Rafael, López, Manuela G., Rodríguez-Franco, María Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958504/
https://www.ncbi.nlm.nih.gov/pubmed/35245051
http://dx.doi.org/10.1021/acs.jmedchem.1c01883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958504/
https://www.ncbi.nlm.nih.gov/pubmed/35245051
http://dx.doi.org/10.1021/acs.jmedchem.1c01883

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